Shop

Description

Vitrase is a highly purified, ovine-derived hyaluronidase (purified from sheep wool) used as an injectable spreading agent. It is designed to temporarily break down hyaluronic acid, the “cement” that holds cells together in the interstitial matrix. In the aesthetic field, Vitrase is a critical tool for the immediate dissolution of hyaluronic acid (HA) fillers, helping to manage complications or refine overfilled areas. Its ovine origin provides a potent enzymatic action with a long history of clinical use in both ophthalmology and dermatology.

Main Benefits of Vitrase

• Rapid Filler Dissolution: Breaks down cross-linked HA filler polymers within minutes of contact, making it indispensable for emergency interventions.

• Correction of Overfilling: Allows practitioners to precisely adjust results by removing excess filler that may have caused lumps, asymmetry, or a “puffy” appearance.

• Enhanced Drug Absorption: Acts as a “molecular door-opener,” increasing the permeability of the tissue to allow other injected fluids or medications to spread more effectively.

• Management of Vascular Occlusions: A primary emergency agent used to restore blood flow if a filler is accidentally injected into a vessel.

• High Potency: The ovine-derived enzyme is known for its high activity levels and effective diffusion through targeted tissue.

Indications

Vitrase is utilized by medical professionals in the following scenarios:

• Hyaluronic Acid Reversal: Dissolving unwanted or misplaced dermal fillers.

• Tyndall Effect Correction: Resolving the bluish hue caused by filler placed too superficially.

• Hypodermoclysis: Facilitating the subcutaneous administration of fluids for hydration.

• Ophthalmic Surgery: Often used in local anesthesia for eye procedures to increase the spread of the anesthetic.

Technical Specifications

Mechanism of Action

Vitrase works through Enzymatic Hydrolysis:

1. Breaking the Barrier: The enzyme hydrolyzes the glucosaminidic bonds of hyaluronic acid, temporarily liquefying the gel-like substance between cells.

2. Increased Permeability: This process lowers the viscosity of the intercellular matrix, allowing for the rapid dispersion of both natural and synthetic hyaluronic acid.

3. Natural Excretion: Once the filler is broken down into smaller saccharide chains, the body’s lymphatic system naturally clears the particles.

4. Tissue Restoration: The effect is temporary; the body regenerates its own natural hyaluronic acid within approximately 24 to 48 hours.

Administration Protocol

• Reconstitution: Often provided as a lyophilized powder that must be reconstituted with sterile, preservative-free saline before use.

• Patch Testing: Because Vitrase is animal-derived (ovine), a skin prick test is generally recommended prior to treatment to rule out hypersensitivity or allergic reactions.

• Injection Technique: Injected directly into the specific deposit of HA filler or the area of concern using a fine-gauge needle.

• Dosage: The number of units required is determined by the practitioner based on the volume and “firmness” (G-prime) of the filler being targeted.

• Professional Note: Vitrase is only effective on Hyaluronic Acid. It will not affect permanent fillers, silicone, or calcium hydroxylapatite (Radiesse).

FAQ

Q: Is Vitrase better than human recombinant hyaluronidase (Hylenex)?

A: Both are highly effective. Vitrase (ovine) has a higher USP unit count per mL (200 units vs 150 units), which some practitioners prefer for dense fillers. However, because it is animal-derived, it requires more caution regarding potential allergies.

Q: How soon can I re-inject filler after using Vitrase?

A: It is generally recommended to wait 10 to 14 days after using hyaluronidase before re-injecting HA filler. This allows the enzyme to dissipate and the tissue to stabilize.

Q: Will it cause a dent in my skin?

A: You may notice a temporary “hollow” feeling as it may dissolve some of your natural HA. This is not permanent; your body will replenish its own natural hyaluronic acid within a few days.

IMPORTANT NOTICE ON INTELLECTUAL PROPERTY

This store operates as an autonomous merchant of genuine medical aesthetic products. We maintain no formal affiliation, partnership, or authorized distribution agreement with the manufacturers of Vitrase or their global subsidiaries. All proprietary names, logos, and trademarks mentioned herein remain the exclusive intellectual property of their rightful owners. Their use on this site is strictly for the identification and description of the original goods we provide as an independent reseller.